Ioan Opris, PhD

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Ioan Opris PhD

Wake Forest University School of Medicine
Department of Physiology & Pharmacology          
Office 263, PTCR
Winston Salem, NC 27157, USA
Phone: (336) 716-8642
Fax:(336) 716-8501
E-mail: ioopris@wakehealth.edu ; ioopris@wfubmc.edu
Personal: Romanian and American Citizen

 Education:

1999-2003 Postdoctoral training in Cognitive & Oculomotor Neuroscience

                 Yale University (Advisers: Charles J. Bruce & Patricia Goldman-Rakic)

1998-1999 Postdoctoral training in Cognitive Neuroscience & Psychiatry

                 NY State Psychiatric Institute, Columbia University (Adviser: Vincent P. Ferrera)

1990-1995 Doctorate, Physics, University of Bucharest, Romania (Adviser: Gheorghe Ciobanu)

                 Dissertation: “Statistical mechanics & nonlinear dynamics of neuronal networks

1978-1982 Bachelor of Science, Physics, University of Bucharest, Romania

                 Major: Biophysics (Adviser: Victor Gheorghe)

                 Thesis: “Biophysical aspects of nervous impulse conduction

Employment and Experience:

2004-          Senior Research Scientist, Department of Physiology and Pharmacology,

                   Wake Forest University School of Medicine

2003-2004   Postdoctoral Research Associate, Department of Anatomy and Neurobiology,

                   Wake Forest University School of Medicine

1999-2003   Postdoctoral Fellow, Department of Neurobiology, Yale University

1998-1999   Postdoctoral Fellow, Center for Neurobiology and Behavior, Columbia University

1995-1998   Postdoctoral Research Associate, Department of Anatomy and Neurobiology,

                   University of Tennessee Memphis

1990-1995  Assistant Professor, Department of Physics, University of Bucharest, Romania

                  Associate Faculty to the Master Program in Neurobiology in Department of Biology

Teaching:

2014-2015 Techniques in Physiology, Graduate Program in Neuroscience, Wake Forest School of    Medicine

Professional Affiliations:

Society for Neuroscience; Society for Neuroeconomics, Society for Brain Mapping and Therapeutics

Awards and Honors:

2014            American Romanian Academy of Arts and Sciences, Member Elected
2014           “American Romanian Academy Award” for Excellence in Physics/Chemistry

Editor/Referee/Evaluation Activity:

  • Section Co- Editor in Chief, Frontiers in Neuroscience, “Neural Nanotechnology”
  • Associate Editor, Research Topic: “Paradigm Shifts in Neuroscience
  • Guest Associate Editor, Frontiers in Systems Neuroscience, Research Topic: “Augmentation of brain function: facts, fiction and controversy
  • Guest Associate Editor, Frontiers in Neuroengineering, Research Topic: “Neural Nanotechnology: Revolutionary approach for neuroscientists
  • 2016 Springer Book Editor with Manuel F Casanova “The Physics of the Mind and Brain Disorders: Integrated Neural Circuits Supporting the Emergence of Mind
  • 2015 Springer Book Co-Editor with Manuel F Casanova “Recent Advances on the Modular Organization of the Cerebral Cortex
  • 2015 Bentham Science Publishers eBook Series Co-Editor with Mikhail A Lebedev “Frontiers in Physiology
  • Co-organizer with Manuel F. Casanova 2013 Conference on Cortical Modularity
  • Reviewer @ Neuroscience and Biobehavioral Reviews, Brain, PLOS One, Brain Research, Journal of Neuroscience Methods, Experimental Brain Research, Neuroscience Letters, Frontiers in Systems Neuroscience, IEEE Transactions on Biomedical Engineering, Journal of Neural Engineering, Cognition, International Journal of Cognitive Science, Colombia Medica, OMICS Publishing Group, Journal of Alcoholism & Drug Dependence.
  • 2015 National Science Foundation, Panelist

Publications (since 2012):

1. Casanova MF, Sokhadze EM, Opris I, Wang Y, Li X (2015) Linking Neuroanatomy and Neuropathology to Treatment with Transcranial Magnetic Stimulation in Autism Spectrum Disorders Acta Paediatrica DOI:10.1111/apa.12943.

2. Deadwyler SA, Berger TW, Opris I, Hampson RE (2014) Neurons and Networks Organizing and Sequencing Memories. Brain Research 12/2014 DOI: 10.1016/j.brainres.2014.12.037.

3. Song D, Chan RH, Robinson BS, Marmarelis VZ, Opris I, Hampson RE, Deadwyler SA, Berger TW (2014). Identification of functional synaptic plasticity from spiking activities using nonlinear dynamical modeling. J Neurosci Methods. S0165-0270(14)00348-3. doi: 10.1016/j.jneumeth.2014.09.023

4. Fetterhoff D, Opris I, Simpson SL, Deadwyler SA, Hampson RE, Kraft RA (2014) Multifractal Analysis of Information Processing in Hippocampal Neural Ensembles During Working Memory under Delta-9 Tetrahydrocannabinol Administration. Journal Neurosci. Methods. doi:1016/j.jneumeth.2014.07.013

5. Opris I, Ferrera VP (2014). Modifying Cognition and Behavior with Microstimulation: Implications for Cognitive Prostheses. Neuroscience and Biobehavioral Reviews 1016/j.neubiorev.2014.09.003.

6. Sokhadze EM, El-Baz AS, Sears LL, Opris I and Casanova MF (2014) Neuromodulation based on rTMS improves electrocortical functional measures of information processing and behavioral responses in autism. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Front Syst. Neurosci. doi: 10.3389/fnsys.2014.00134.

7. Vidu R, Rahman M, Mahmoudi M, Enachescu M, Poteca TD, Opris I, (2014) Nanostructures: A Platform for Brain Augmentation. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Syst. Neurosci. 8:91. doi: 10.3389/fnsys.2014.00091.

8. Opris I, Gerhardt GA, Hampson RE, Deadwyler SA (2014) Prefrontal cortical recordings with biomorphic MEAs reveals complex columnar-laminar microcircuits for BMI implementation. Neurosci. Methods DOI: 10.1016/j.jneumeth.2014.05.029.

9. Opris I, Casanova MF (2014). Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing. Brain, doi: 1093/brain/awt359.

10. Santos LM, Opris I, Hampson RE, Godwin DW, Gerhardt GA, Deadwyler SA (2014) Functional dynamics of primate cortico-striatal networks during volitional movements. Syst. Neurosci. 8: 27.

11. Hampson RE, Song D, Opris I, Santos LM, Shin D, Gerhardt GA, Marmaarelis, V, Berger TW, Deadwyler SA (2013) Facilitation of Memory Encoding in Primate Hippocampus by a Neuroprosthesis that Promotes Task Specific Neural Firing. J Neural 10 (6), 066013 .

12. Deadwyler S,A Hampson RE, Song D, Chan RHM, Opris I, Gerhardt GA, Marmaarelis, V, Berger TW (2013) Donor/Recipient Enhancement of Memory in Rat Hippocampus. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Syst. Neurosci. 7: 120.

13. Opris I (2013) Inter-Laminar Microcircuits across the Neocortex: Repair and Augmentation. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Syst. Neurosci. 7:80. doi: 10.3389/fnsys.2013.00080.

14. Hampson RE, Fuqua JL. Huettl P, Opris I, Song D, Shin D, Marmaarelis, V, Berger TW, Gerhardt GA, Deadwyler SA (2013) Conformal Ceramic Electrodes That Record Glutamate Release and Corresponding Neural Activity in Primate Prefrontal Cortex. Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE. Osaka, Japan. pp. 5954 – 5957.

15. Opris I, Santos LM, Song D, Berger TW, Gerhardt GA, Hampson RE and Deadwyler SA (2013) Prefrontal cortical microcircuits bind perception to executive control. Scientific Reports 3:2285.

16. Porrino LJ, Hampson RE, Opris I, Deadwyler SA (2013) Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen. Psychopharmacology, DOI: 10.1007/s00213-012-2798-6.

17. Opris I, Fuqua JL. Huettl P, Gerhardt GA, Berger TW, Hampson RE, Deadwyler SA (2012) Closing the loop in primate prefrontal cortex: Inter-laminar processing. Neural Circuits. 6:88.

18. Opris I. Hampson RE, Gerhardt GA, Berger TW, Deadwyler SA (2012) Columnar processing in primate prefrontal cortex: Evidence for executive control microcircuits. Cogn. Neuro 24(12):2334-47.

19. Hampson RE, Gerhardt GA, Marmarelis VZ Song D, Opris I, Santos LM, Berger TW, Deadwyler SA (2012) Facilitation and Restoration of Cognitive Function in Primate Prefrontal Cortex by a Neuroprosthesis that Utilizes Minicolumn-Specific Neural Firing. J Neural Eng. 9(5):056012.. Featured by The New York Times:

20. Hampson RE, Opris I, Song D, Gerhardt GA, Shin D, Marmarelis VZ, Berger TW, Deadwyler SA (2012) Neural representation of cognitive processing in prefrontal cortex of nonhuman primates during a delayed match-to-sample task. Conf Proc IEEE Eng Med Biol Soc, 2559-2560.

21. Song D, Opris I, Chan RHM, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW (2012) Functional conectivity between layer 2/3 and layer 5 neurons the prefrontal cortex of nonhuman primates. Conf Proc IEEE Eng Med Biol Soc, Page(s): 2555 – 2558.

22. Santos LM, Opris I, Fuqua J, Hampson RE, Deadwyler SA (2012) A novel tetrode microdevice for simultaneous single-unit recording and microstimulation of several brain regions in primates. J. Neurosci Methods, DOI 10.1016/j.jneumeth.2012.01.006.

In Press:

23. Opris I, Santos LM, Gerhardt GA, Song D, Berger TW, Hampson RE and Deadwyler SA (2015) Distributed Encoding of Spatial and Object Categories in Primate Hippocampal Microcircuits. Scientific Reports @ Nature.

24. Opris I, Gerhardt GA, Hampson RE, Deadwyler SA (2015) Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure. Submitted for Research Topic: “Structural and functional organization of the prefrontal cortex” Tinsley CJ (ed.). Syst. Neurosci.

25. Opris I, Lebedev MA, Sokhadze E, Casanova MF (2015) Repair and Augmentation of Cognition: Neural Stimulation and Brain-Machine Interfaces. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Syst. Neurosci.

26. Lebedev MA, Opris I, Casanova MF (2015) Brain-Machine Interfaces and Brain Plasticity. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Syst. Neurosci.

27. Lebedev MA, Opris I. (2015) Reading the mind: from neuromarketing to cognitive brain-machine interfaces. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Syst. Neurosci.

28. Lebedev MA, Opris I. (2015) A brain-machine interface with sound output: a pathway to speech synthesis. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I and Casanova MF (ed.), Syst. Neurosci.

In Submission:

29. Ciurea A, Mindruta I, Malaia M, Donos C, Barborica A, Ciurea J, Opris I. (2015) Startle Epilepsy in Anterior Cingulate Cortex. (Epilepsia).

30. Koene R, Hayworth K, Angelica A, Domschke A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev M, Freitas Jr RA (2015) “Facilitating a Neocortical/Cloud Interface – Conceptual Nanomedical Strategies”. (PLOS one)

31. Opris I, Hampson RE, Gerhardt GA, Deadwyler SA (2015) Perceptual and executive control gating in primate prefrontal cortical microcircuits.

32. Opris I, Santos, LM, Fetterhoff D, Sexton, CA, Hampson RE, Deadwyler SA (2014) Contextual information processing during memory encoding and categorization by primate hippocampal microcircuits spanning over subfields CA1 & CA3. Abstract accepted for Research Topic: “Memory Processes in Medial Temporal Lobe: Experimental, Theoretical and Computational Approaches” hosted by: Motoharu Yoshida, Vassilis Cutsuridis. ( Syst. Neurosci.)

33. Opris I, Lebedev M, (2015) MIMO Models vs. Associative Memories with Non-Monotonic Neurons: Roots of Cognitive Enhancement. Research Topic: “Augmentation of brain function: facts, fiction and controversy”, Lebedev MA, Opris I, Casanova MF (ed.), Syst. Neurosci.

34. Opris I, Santos, LM, Klorig DC, Godwin DW, Weiner JL, Gerhardt GA, Deadwyler SA Hampson RE (2015) “Optogenetic neuromodulation of hippocampal activity in primates”. (Nature Neuroscience).

Books:

35. Manuel F. Casanova, Ioan Opris, editors. Recent Advances on the Modular Organization of the Cortex. New York: Springer; 2015 (in press).

36. Ioan Opris, Manuel F. Casanova, editors. The Physics of the Mind and Brain Disorders: Integrated Neural Circuits Supporting the Emergence of Mind”. New York: Springer; 2016 (under contract).

37. Mikhail A Lebedev, Ioan Opris, “Frontiers in Physiology” Bentham Science Publishers, eBook Series 2015 (in preparation).

38. Mikhail A Lebedev, Ioan Opris, Manuel F. Casanova, editors.. “Augmentation of brain function: facts, fiction and controversy” Lausanne: Frontiers Media SA ebook. 2015 (in preparation).

Book Chapters:

39. Opris I, Lebedev M, Nelson RJ (2011) Motor planning under unpredictable reward: modulations of movement vigor and primate striatum activity. Neurobiology of Choice, Editors: Daeyeol Lee, Paul Glimcher, Julia Trommershaeuser, Frontiers Media SA ebook.

40. Opris I, Fuqua JL. Huettl P, Gerhardt GA, Berger TW, Hampson RE, Deadwyler SA (2014) Closing the loop in primate prefrontal cortex: Inter-laminar processing.. Potter, S. M., El Hady, A., Fetz, E. E., (eds.) Closing the Loop Around Neural Systems. Lausanne: Frontiers Media SA ebook. doi: 10.3389/978-2-88919-356-1

41. Song D, Hsiao M-C, Opris I, Hampson RE, Marmarelis VZ, Gerhardt GA, Deadwyler SA Berger TW (2015) Hippocampal Microcircuits, Functional Connectivity and Prosthetics. In “Recent Advances on the Modular Organization of the Cerebral Cortex”, Editor(s): Manuel F Casanova and Ioan Opris, Springer book (in press).

42. Deadwyler SA Opris I, Santos LM, Hampson RE, Gerhardt GA, Song D, Marmarelis VZ, Berger TW (2015) Extraction of Cortical Modularity Patterns for Neural Prosthetics. In “Recent Advances on the Modular Organization of the Cerebral Cortex”, Editor(s): Manuel F Casanova and Ioan Opris, Springer book (in press)

43. Opris I. Popa IL, Manuel F. Casanova (2015) Prefrontal Cortical Microcircuits of Executive Control. In “Recent Advances on the Modular Organization of the Cerebral Cortex”, Editor(s): Manuel F Casanova and Ioan Opris, Springer book (in press).

44. Lebedev MA, Opris I (2015). Brain Machine Interfaces: From Macro- to Microcircuits. In “Recent Advances on the Modular Organization of the Cerebral Cortex”. Editor(s): Manuel F Casanova and Ioan Opris, Springer book (in press).

45. Gerhardt GA, Opris I, Burmeister JJ, Pomerleau F, Quintero JE, Huettl P, Hampson RE, Deadwyler SA (2015). The Function of Microcircuits: Insights from Biomorphic Ceramic-based Micro-electrode Arrays. In “Recent Advances on the Modular Organization of the Cerebral Cortex” Editor(s): Manuel F Casanova and Ioan Opris, Springer book (in press).

46. Enachescu M, Vidu R, Opris I. (2015) Uncovering Cortical Modularity by Nanotechnology. In “Recent Advances on the Modular Organization of the Cerebral Cortex”, Editor(s): Manuel F Casanova and Ioan Opris, Springer book (in press).

47. Ciurea A, Mindruta I, Ciurea Al, Ciurea J, Barborica A, Donos C, Casanova MF, Opris I. (2015) Modular Signatures and Neural Avalanches in Epileptic Brain Networks. In “Recent Advances on the Modular Organization of the Cerebral Cortex”, Editor(s): Casanova MF and Opris I, Springer book (in press)

48. Opris I. Popa IL, Manuel F. Casanova (2015) Electrical stimulation for modification of memory and cognition. Chapter 10 in “Electroceuticals: Advances in Electrostimulation Therapies”, edited by Dr. Arshad Majid, Springer Science textbook (invited, in press).

Invited Talks & Seminars:

  • Conference “Pathology 2015”, Invited talk, London, December 1-3, 2015
  • National Society for Neuroscience Conference, Invited plenary talk, Bucharest, Romania, Oct 29-31, 2015
  • American Romanian Academy of Arts and Sciences, Frascati, Roma, Italy, July 28-31, 2015
  • International Forum for Integrative Medicine, Romanian Academy, Invited talk, Bucharest, Jun 26-28, 2015.
  • 12th World Congress on Brain Mapping and Therapeutics, Invited Talk, Los Angeles, March 6-8, 2015.
  • International Forum for Integrative Medicine, Romanian Academy, Invited talk, Bucharest, Nov 29, 2014.
  • “Titu Maiorescu” University, Invited talk, Bucharest, Romania, Oct 25, 2014
  • National Society for Neuroscience Conference, Invited plenary talk, Bucharest, Romania, Oct 24, 2014
  • American Romanian Academy of Arts and Sciences, Caltech, Pasadena, July 2014
  • Symposium on Cortical Modularity, Louisville, KY, August 2013

In the News (Selected from more than 50 links):

  1. New York Times, 09/14/2012 Brain implant improves thinking in monkeys, first such demonstration in primates” by Benedict Carey
  2. Science Daily: 09/13/2012 „Scientists use prosthetic device to restore and improve impaired decision-making ability in animals”
  3. Wake Forest Baptist Medical Center: 09/13/2012 “Scientists use prosthetic device to restore and improve impaired decision-making ability in animals”
  4. Truth dive: 09/16/2012 Prosthetic device used to repair decision-making ability in monkeys
  5. Diagnostic Supplies 09/17/2012 ‘Scientists use prosthetic device to restore and improve impaired decision-making ability in animals
  6. Health Medicine Articles 09/12/2012 “Researchers have taken a key step towards recovering specific brain functions in sufferers of brain disease and injuries by successfully restoring the decision-making processes in monkeys.”
  7. Associazione Alzheimer Riese 09/18/2012:” Impianto nel cervello potrebbe aumentare la funzione cognitiva con demenza e ictus“.
  8. Canberra Times 09/16/2012: “A chip to repair the brain”
  9. The Kurzweil Accelerating Intelligence 09/19/2012: “Prosthetic device restores impaired decision-making ability”
  10. Icafcoalition.org 09/15/2012 “Scientists use prosthetic device to restores impaired decision-making ability in animals”
  11. Romania Libera Online 09/16/2012 “A Romanian has contributed to the invention of brain implant”
  12. Gandul Info, Romania 09/28/2012 “Descoperirea in medicina pentru care un roman ar putea lua premiul Nobel”
  13. Cortical Chauvinism, 01/24/2013 An Introduction to Cortical Modularity, by Manuel F Casanova
  14. Cortical Chauvinism, 08/15/2013 Photographs of the Congress in Louisville, Kentucky, 2013.
  15. Jenni Laidman, August, 2013 Louisville Magazine, Trouble in mind. Can magnetic energy change the face of autism?
  16. Hitoki Nakagawa, /03/20/2014, Asahi Shimbun, Japan (in japanese), ” Excellent brains from the world gather in the United States “http://globe.asahi.com/feature/side/2014031800002.html
  17. Tiago Cordeiro, 04/25/2014, Em busca do cérebro immortal, Revista Galileu, Globo, Brazil;
    http://revistagalileu.globo.com/Revista/noticia/2014/04/em-busca-do-cerebro-imortal.htm